Analysis Tools
behavior/neurological
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• increased preference for dark in dark/light choice test at 14 weeks of age
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• observed at 6 and 14 weeks of age in both sexes
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• mice exhibit a progressive impairment on the rotarod test beginning at 8 weeks of age
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• progressive deterioration of grip strength especially in males at 14 weeks of age
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• narrower base (separation between legs) than controls
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• shorter splay length (contralateral) than controls at 14 weeks of age
• stride length (ipsilateral) is similar to controls
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• mice rear less in the center of the open field test than controls starting at 12 weeks of age in the light phase
• rearing is similar to controls in dark phase
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• mice cover less total distance in light phase of open field test starting at 6 weeks of age in females and 8 weeks of age in males
• mice cover less distance in center starting at 12 weeks in light phase and 6 weeks in dark phase
• in dark phase, hypoactivity is significant at 6 weeks of age in both sexes
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growth/size/body
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• body weight decreases by 10 weeks of age in females and 9 weeks in males
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mortality/aging
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• median survival of 141 days for females and 179 days for males
• all mice die within 9 weeks of the first death
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nervous system
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• observed at 14 weeks of age, especially in females
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