Analysis Tools
behavior/neurological
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• increased preference for dark in dark/light choice test at 12 and 14 weeks of age
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• beginning at 4 weeks of age
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• mice exhibit a reduced latency to fall on rotarod test beginning at 4 weeks of age as compared to wild-type
• latency time decreases with age
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• progressive deterioration of grip strength especially in males between 10-14 weeks of age
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• wider base (separation between legs) than controls; females exhibit difference earlier than males
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• decreased stride length (ipsilateral) observed at 8 weeks of age
• shorter splay length (contralateral) than controls
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• mice rear less in the center of the open field test than controls at all ages in the light phase and by 6 weeks of age in the dark phase
• mice exhibit a progressive decrease in climbing activity starting at 4 weeks of age
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• mice are hypoactive in the open field test in both the light and dark phases of the light cycle
• in the light phase females are less active at 8 and 14 weeks of age
• in the light phase males are less active starting at 6 weeks of age
• in the dark phase both sexes are hypoactive beginning at 12 weeks of age
• progressive hypoactivity is observed in the center of the open field beginning at 4 weeks of age
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growth/size/body
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• decrease in body weight is observed by 7 weeks in both sexes
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mortality/aging
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• median survival of 113 days
• all mice die within 12 weeks of the first death
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nervous system
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• observed after 8 weeks of age
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