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Phenotypes Associated with This Genotype
Genotype
MGI:5428893
Allelic
Composition
Lepob/Lepob
Genetic
Background
BTBR.Cg-Lepob/WiscJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (6 available); any Lep mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice do not develop atherosclerosis (J:185261)
• mice do not develop atherosclerosis (J:185261)

growth/size/body
• body weight is increased by 8 weeks of age as compared to heterozygotes and wild-type (J:185261)
• body weight is increased by 8 weeks of age as compared to heterozygotes and wild-type (J:185261)

homeostasis/metabolism
• increased BUN levels in both male and female mice (J:185261)
• increased BUN levels in both male and female mice (J:185261)
• hyperglycemia is more evident in males than females, but after a time delay, also occurs in females (J:106121)
• hyperglycemia is more evident in males than females, but after a time delay, also occurs in females (J:106121)
• mice exhibit hyperglycemia by 8 weeks of age (J:185261)
• males progress to blood glucose levels of 399 +/- 38.8 mg/dl by 22 weeks of age (J:185261)
• females progress to blood glucose levels of 333 +/- 46.3 mg/dl by 22 weeks of age (J:185261)
• Background Sensitivity: blood glucose levels are higher than obese mice on the C57BL/6 background (J:185261)
• mice exhibit hyperglycemia by 8 weeks of age (J:185261)
• males progress to blood glucose levels of 399 +/- 38.8 mg/dl by 22 weeks of age (J:185261)
• females progress to blood glucose levels of 333 +/- 46.3 mg/dl by 22 weeks of age (J:185261)
• Background Sensitivity: blood glucose levels are higher than obese mice on the C57BL/6 background (J:185261)
• mice are hyperinsulinemic by 6 weeks of age but levels decrease as glucose levels rise (J:106121)
• mice are hyperinsulinemic by 6 weeks of age but levels decrease as glucose levels rise (J:106121)
• increased serum triglyceride levels in both male and female mice (J:185261)
• increased serum triglyceride levels in both male and female mice (J:185261)
• inability to clear plasma glucose following an overnight fast (J:106121)
• inability to clear plasma glucose following an overnight fast (J:106121)
• at 6 weeks of age, most females are insulin resistant; they are hyperinsulinemic while maintaining only moderately elevated glucose levels (J:106121)
• by 10 weeks of age, female mice are hyperglycemic while still maintaining high (but insufficient) levels of insulin (J:106121)
• by 14 weeks of age, many females have even lower plasma insulin and increasing plasma glucose levels (J:106121)
• males show a similar progression of insulin resistance as females but starting at an earlier age, showing high insulin and high glucose at 6 weeks of age (J:106121)
• at 6 weeks of age, most females are insulin resistant; they are hyperinsulinemic while maintaining only moderately elevated glucose levels (J:106121)
• by 10 weeks of age, female mice are hyperglycemic while still maintaining high (but insufficient) levels of insulin (J:106121)
• by 14 weeks of age, many females have even lower plasma insulin and increasing plasma glucose levels (J:106121)
• males show a similar progression of insulin resistance as females but starting at an earlier age, showing high insulin and high glucose at 6 weeks of age (J:106121)
• increased cholesterol levels in both male and female mice (J:185261)
• increased cholesterol levels in both male and female mice (J:185261)
• albuminuria is detected as early as 8 weeks of age, progressing to a 10-fold difference by 20 weeks of age (J:185261)
• increased albumin creatinine ratio (J:185261)
• albuminuria is detected as early as 8 weeks of age, progressing to a 10-fold difference by 20 weeks of age (J:185261)
• increased albumin creatinine ratio (J:185261)

renal/urinary system
• albuminuria is detected as early as 8 weeks of age, progressing to a 10-fold difference by 20 weeks of age (J:185261)
• increased albumin creatinine ratio (J:185261)
• albuminuria is detected as early as 8 weeks of age, progressing to a 10-fold difference by 20 weeks of age (J:185261)
• increased albumin creatinine ratio (J:185261)
• reduced podocyte density (J:185261)
• reduced podocyte number (J:185261)
• reduced podocyte density (J:185261)
• reduced podocyte number (J:185261)
• glomerular basement membrane thickness is increased by 18% as compared to wild-type (J:185261)
• glomerular basement membrane thickness is increased by 18% as compared to wild-type (J:185261)
• renal lesions are characterized by increased glomerular mesangial matrix accumulation (J:185261)
• renal lesions are characterized by increased glomerular mesangial matrix accumulation (J:185261)
• mesangiolysis is observed in 8% of glomeruli 8 week old mice (J:185261)
• mesangiolysis increases with age reaching 33.1% by 22 weeks of age (J:185261)
• diffuse mesangial sclerosis (J:185261)
• mesangiolysis is observed in 8% of glomeruli 8 week old mice (J:185261)
• mesangiolysis increases with age reaching 33.1% by 22 weeks of age (J:185261)
• diffuse mesangial sclerosis (J:185261)
• increased glomerular size (J:185261)
• increased glomerular size (J:185261)
• focal and mild interstitial fibrosis is observed in 12 week old mice (J:185261)
• interstitial collagen accumulation is increased at 24 weeks of age as compared to wild-type (J:185261)
• focal and mild interstitial fibrosis is observed in 12 week old mice (J:185261)
• interstitial collagen accumulation is increased at 24 weeks of age as compared to wild-type (J:185261)
• renal hypertrophy (J:185261)
• renal hypertrophy (J:185261)
• both sexes exhibit increased kidney weight as compared to wild-type (J:185261)
• kidney weight of males is increased compared to females (J:185261)
• both sexes exhibit increased kidney weight as compared to wild-type (J:185261)
• kidney weight of males is increased compared to females (J:185261)

endocrine/exocrine glands
• architecture of islets is disrupted, with many noninsulin staining cells in the central core (J:106121)
• whole pancreas insulin content is reduced by 75-80% compared to mutants on the C57BL/6 background (J:106121)
• architecture of islets is disrupted, with many noninsulin staining cells in the central core (J:106121)
• whole pancreas insulin content is reduced by 75-80% compared to mutants on the C57BL/6 background (J:106121)
• many small islets that show poor insulin staining (J:106121)
• many small islets that show poor insulin staining (J:106121)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:106121


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory