Analysis Tools
endocrine/exocrine glands
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• embryos show an increase in Neurog3+ve cells at E9.5; by E10.5, an increase in glucagon+ve cells is seen
• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos
• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are reduced in the proximal domain by 75% while Hnf1b and DBA+ve cells are reduced in number
• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with a corresponding increase in Nkx6-1-ve Ptf1a+ve cells
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• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos
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cellular
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• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos
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