Analysis Tools
endocrine/exocrine glands
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• loss of DBA+ve (D. biflorus agglutinin) duct structures is observed by E18.5
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• at E9.5, an excess of Neurog3+ve cells is found in the dorsal pancreatic bud; near complete conversion of dorsal bud cells to glucagon+ve cells occurs by E10.5
• at E10.5, dorsal pancreas is absent, but ventral pancreatic anlage forms normally
• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are absent from the proximal domain while Hnf1b and DBA+ve cells are also lost, with a concurrent increase in Nkx6-1-ve, Ptf1a+ve cells as well as Cpa+ve and amylase +ve cells
• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with a corresponding increase in Nkx6-1-ve Ptf1a+ve cells
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• insulin-producing cells are absent by E18.5
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digestive/alimentary system
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• loss of DBA+ve (D. biflorus agglutinin) duct structures is observed by E18.5
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cellular
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• insulin-producing cells are absent by E18.5
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