Phenotypes Associated with This Genotype

Genotype
MGI:5427999

• Allelic Composition: Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc; Tg(Cdh16-cre)91Igr/0
• Genetic Background: involves: 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151498 )

• most mice die between P30 and P45 with no mice surviving past P60

renal/urinary system

kidney cyst ( J:151498 )

• delayed compared to in Wnt9b^tm1Amc homozygotes

• few cysts at P1

• prevalent by P10

• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct

renal glomerulus cyst ( J:151498 )

abnormal kidney collecting duct epithelium morphology ( J:151498 )

• collecting duct epithelial cells exhibit randomized elongation unlike in wild-type mice

abnormal renal tubule epithelium morphology ( J:151498 )

• at P5, epithelium cell divisions are not oriented within the plane of the epithelium unlike in control mice

• by P30, little normal epithelia remains

dilated renal tubule ( J:151498 )

growth/size/body

kidney cyst ( J:151498 )

• delayed compared to in Wnt9b^tm1Amc homozygotes

• few cysts at P1

• prevalent by P10

• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct

renal glomerulus cyst ( J:151498 )