Phenotypes Associated with This Genotype

Genotype
MGI:5427953

• Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1.2Jsv; Sle21^129P2/Ola/Sle21^C57BL/6
• Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:179175 )

• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice

immune system

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased susceptibility to systemic lupus erythematosus ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-chromatin antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-double stranded DNA antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-histone antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-single stranded DNA antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

renal/urinary system

albuminuria ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

abnormal kidney morphology ( J:179175 )

• kidney pathology is increased compared to in wild-type C57BL/6 mice

homeostasis/metabolism

albuminuria ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

hematopoietic system

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

growth/size/body

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes