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Phenotypes Associated with This Genotype
Genotype
MGI:5427869
Allelic
Composition
Cdc42tm1Brak/Cdc42tm1Brak
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Brak mutation (0 available); any Cdc42 mutation (44 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• one week after tamoxifen administration, 56% of mutant crypts show stem cells forming a clustering pattern lacking clear demarcation between each other, while at 3 weeks after tamoxifen administration, 85% do so
• stem cells in mutant crypts 3 weeks after tamoxifen treatment lose the typical triangle shapes and marker analysis indicates disrupted crypt cell polarity
• loss of stem cells
• intestinal crypt cells, most likely Paneth cells, contain large vacuoles
• reduction or absence of Paneth cell granules, indicating loss of Paneth cells

endocrine/exocrine glands
• one week after tamoxifen administration, 56% of mutant crypts show stem cells forming a clustering pattern lacking clear demarcation between each other, while at 3 weeks after tamoxifen administration, 85% do so
• stem cells in mutant crypts 3 weeks after tamoxifen treatment lose the typical triangle shapes and marker analysis indicates disrupted crypt cell polarity
• loss of stem cells
• intestinal crypt cells, most likely Paneth cells, contain large vacuoles
• reduction or absence of Paneth cell granules, indicating loss of Paneth cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory