Phenotypes Associated with This Genotype

Genotype
MGI:5427828

• Allelic Composition: Drd1^{tm1.1(IL2RA/Venus)Koba}/Drd1⁺
• Genetic Background: B6.129S6-Drd1^{tm1.1(IL2RA/Venus)Koba}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:184374 )

N • immunotoxin-injected mice exhibit normal spontaneous locomotion, motor learning and motivational behavior

abnormal operant conditioning behavior ( J:184374 )

• in a two-choice reaction time task dependent on light stimulus, immunotoxin-injected mice exhibit lengthened motor response compared with wild-type mice

• however, accuracy is normal

nervous system

abnormal neuron morphology ( J:184374 )

• following unilateral injection of immunotoxin, mice exhibit a loss DRD1A- and preprotachykinin-A (PPTA/TAC1)-containing neurons restricted to the dorsal region of the striatum