Drd1^{tm1.1(IL2RA/Venus)Koba}
Targeted Allele Detail

Summary

• Symbol: Drd1^{tm1.1(IL2RA/Venus)Koba}
• Name: dopamine receptor D1; targeted mutation 1.1, Kazuto Kobayashi
• MGI ID: MGI:5427817
• Synonyms: Drd1^KI
• Gene: Drd1 Location: Chr13:54205202-54209677 bp, - strand Genetic Position: Chr13, 28.4 cM
• Alliance: Drd1^{tm1.1(IL2RA/Venus)Koba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184374
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Venus reporter fused to human IL2RA with a polydaenylation sequence and a floxed neo cassette was inserted upstream of exon 2. Cre-mediated recombination removed the neo cassette. Treatment with a recombinant immunotoxin (variable anti-IL2RA regions fused to a bacterial exotoxin fragment) results in ablation of cells expressing this allele. (J:184374)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd1 Mutation: 68 strains or lines available

References

• Original: J:184374 Fukabori R, et al., Striatal direct pathway modulates response time in execution of visual discrimination. Eur J Neurosci. 2012 Mar;35(5):784-97
• All: 2 reference(s)