Phenotypes Associated with This Genotype

Genotype
MGI:5427584

• Allelic Composition: Pik3ca^tm1.1Waph/Pik3ca⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hyperproliferation of the ovarian surface epithelium in Pik3ca^tm1.1Waph/Pik3ca^tm1.1Waph mice

cellular

decreased fibroblast apoptosis ( J:184382 )

• in mouse embryonic fibroblasts after cre-expressing adenovirus infection

increased fibroblast proliferation ( J:184382 )

• in mouse embryonic fibroblasts after cre-expressing adenovirus infection

reproductive system

abnormal ovary morphology ( J:184382 )

♀ • the ovarian surface epithelium of mice infected with a cre-expressing adenovirus exhibit mild, focal papillary serous hyperplasia compared with control mice

endocrine/exocrine glands

abnormal ovary morphology ( J:184382 )

♀ • the ovarian surface epithelium of mice infected with a cre-expressing adenovirus exhibit mild, focal papillary serous hyperplasia compared with control mice