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Phenotypes Associated with This Genotype
Genotype
MGI:5427446
Allelic
Composition		 Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3tm1c(EUCOMM)Wtsi mutation (1 available); any Pik3c3 mutation (48 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:182628 )
• livers from fed and starved exhibit blocked autophagy flux compared with control livers

cellular
abnormal autophagy ( J:182628 )
• livers from fed and starved exhibit blocked autophagy flux compared with control livers

homeostasis/metabolism
abnormal autophagy ( J:182628 )
• livers from fed and starved exhibit blocked autophagy flux compared with control livers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory