Phenotypes Associated with This Genotype

Genotype
MGI:5427440

• Allelic Composition: Nrarp^tm1Ybes/Nrarp^tm1Ybes
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

rib fusion ( J:183027 )

• partial in some ribs

abnormal vertebrae morphology ( J:183027 )

• abnormally shaped in some mice

decreased caudal vertebrae number ( J:183027 )

• in most mice

decreased lumbar vertebrae number ( J:183027 )

• in most mice

embryo

prolonged somite segmentation clock period ( J:183027 )

• segmentation clock period is longer than in wild-type mice

• the ~2-hr segmentation period is extended by 5 min

incomplete somite formation ( J:183027 )

• fewer somites than in wild-type mice at E10.5

• however, treatment with a Notch activity inhibitor (LY411,575) restores somite differentiation

limbs/digits/tail

decreased caudal vertebrae number ( J:183027 )

• in most mice

kinked tail ( J:183027 )

• in 22 of 55 mice