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Phenotypes Associated with This Genotype
Genotype
MGI:5426986
Allelic
Composition		 Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2btm1Bbd mutation (1 available); any Cdkn2b mutation (7 available)
Nkx2-5tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:184521 )
• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage
abnormal spleen mesenchyme morphology ( J:184521 )
• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b

immune system
abnormal spleen morphology ( J:184521 )
• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage
abnormal spleen mesenchyme morphology ( J:184521 )
• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory