Phenotypes Associated with This Genotype

Genotype
MGI:5425003

• Allelic Composition: Acta1^tm1Hrd/Acta1⁺; Tg(ACTA1-FHL1)#Cmit/?
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:184588 )

N • mobility in open field tests is normal

increased grip strength ( J:184588 )

• forearm grip strength is improved

mortality/aging

premature death ( J:184588 )

• survival is not affected by the presence of the transgene

muscle

abnormal muscle fiber morphology ( J:184588 )

• nemaline rod pathology is improved

• increased myofiber size

abnormal muscle weight ( J:184588 )

• improved