Phenotypes Associated with This Genotype

Genotype
MGI:5319692

• Allelic Composition: Tg(Kap-Ppara/AGT)562Dpo/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:172337 )

• improved survival following cisplatin exposure in mice pretreated with testosterone

renal/urinary system

abnormal kidney physiology ( J:172337 )

• decrease in cisplatin induced acute kidney injury in mice pretreated with testosterone

decreased susceptibility to kidney reperfusion injury ( J:172337 , J:183786 )

• in mice pretreated with testosterone (J:172337)

• in mice pretreated with testosterone the appearance of myofibroblasts is inhibited and interstitial fibrosis is reduced following unilateral ureteral obstruction (J:183786)

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:172337 )

• improved survival following cisplatin exposure in mice pretreated with testosterone

decreased physiological sensitivity to xenobiotic ( J:172337 )

• decrease in cisplatin induced acute kidney injury in mice pretreated with testosterone

decreased susceptibility to kidney reperfusion injury ( J:172337 , J:183786 )

• in mice pretreated with testosterone (J:172337)

• in mice pretreated with testosterone the appearance of myofibroblasts is inhibited and interstitial fibrosis is reduced following unilateral ureteral obstruction (J:183786)