Tg(Kap-Ppara/AGT)562Dpo
Transgene Detail

Summary

• Symbol: Tg(Kap-Ppara/AGT)562Dpo
• Name: transgene insertion 562, Didier Portilla
• MGI ID: MGI:5319689
• Synonyms: Kap2-Ppara
• Transgene: Tg(Kap-Ppara/AGT)562Dpo Location: unknown
• Alliance: Tg(Kap-Ppara/AGT)562Dpo page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: androgen
• Mutation: Insertion
• Mutation details: A 1542 bp fragment of the Kap promoter drives expression of a FLAG-tagged Ppara gene and exons 3-5 and 3' untranslated region of the human angiotensin gene. Three lines were generated (560, 561, 562). This line had the highest level of transgene expression in the kidney. Testosterone treatment induces higher levels of transgene expression in the kidneys of female mice. (J:172337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:172337 Li S, et al., Transgenic expression of proximal tubule peroxisome proliferator-activated receptor-alpha in mice confers protection during acute kidney injury. Kidney Int. 2009 Nov;76(10):1049-62
• All: 3 reference(s)