Phenotypes Associated with This Genotype

Genotype
MGI:5319636

• Allelic Composition: Agrp^{tm2(HBEGF)Rpa}/Agrp⁺; Lep^ob/Lep^ob
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:181947 )

• young adult mice stop eating and would succumb following treatment with diptheria toxin

• older moderately obese (35-40 g) mice survive diptheria toxin treatment despite weight loss

• however, mice that weigh over 40 g succumb following treatment with diptheria toxin

• norepinephrine treatment prevents prolongs the survival of diptheria toxin treated mice that weigh over 40 g

nervous system

decreased neuron number ( J:181947 )

• loss of agouti-related protein expressing neurons following treatment with diptheria toxin

behavior/neurological

abnormal eating behavior ( J:181947 )

• following treatment with diptheria toxin young adult mice gradually stop eating by day 6 post treatment

• older, moderately obese mice that are able to survive the weight loss resume feeding about 18 days after treatment

growth/size/body

decreased body weight ( J:181947 )

• diptheria toxin treated older moderately obese mice weigh less than saline treated controls for several months after treatment

weight loss ( J:181947 )

• following treatment with diptheria toxin mice lose 20% of their body weight

homeostasis/metabolism

decreased body temperature ( J:181947 )

• diptheria toxin treatment of mice that weigh over 40 g results in a sharp drop in body temperature to near ambient temperature as mice become moribund

• norepinephrine treatment prevents the drop in body temperature

improved glucose tolerance ( J:181947 )

• glucose tolerance is improved in diptheria toxin treated mice relative to saline treated controls and is not significantly different from mice heterozygous for Lep^ob alone

reproductive system

enhanced fertility ( J:181947 )

• following diptheria toxin treatment of older moderately obese mice, both males and females become fertile, unlike saline treated mice which remain infertile