Phenotypes Associated with This Genotype

Genotype
MGI:5319228

• Allelic Composition: Lepr^tm1.2Chua/Lepr^tm1.2Chua; Nos1^tm1(cre)Mgmj/Nos1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:183754 )

behavior/neurological

increased food intake ( J:183754 )

• males show increased food intake relative to controls; females display similar trend

decreased locomotor activity ( J:183754 )

• at 12-14 weeks, males show decreased ambulatory activity in both dark and light cycles in 24-hour period

• females show decreased ambulatory activity during both light and dark cycles; this is more significant than in females with conditional deletion of Lepr

growth/size/body

increased body weight ( J:183754 )

• males have higher body weight relative to controls at 12-14 weeks; females display similar trend

homeostasis/metabolism

decreased circulating thyroxine level ( J:183754 )

• levels of T4 are lower in males compared to controls; levels are higher than in conditional Lepr knockout males

increased circulating glucose level ( J:183754 )

• higher than controls from weaning age on in males and females

increased circulating corticosterone level ( J:183754 )

• levels are higher in males than in controls

increased circulating insulin level ( J:183754 )

• starting at weaning age (8 weeks), much higher than controls at 8 weeks in both males and females

increased circulating leptin level ( J:183754 )

• starting at weaning age (8 weeks), much higher than controls in both males and females

decreased oxygen consumption ( J:183754 )

• males show decreased maximal oxygen consumption relative to controls at 12-14 weeks

• females display a similarly decreased VO2

reproductive system

reduced female fertility ( J:183754 )

♀ • majority of females fail to deliver litters within 6 weeks of mating