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Phenotypes Associated with This Genotype
Genotype
MGI:5318858
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Smn1tm1Cdid/Smn1tm1Cdid
Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic
Background
involves: 129 * 129S1/Sv * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm7Tg(SMN2)89Ahmb mutation (35 available); any Grm7 mutation (123 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (28 available)
Smn1tm1Cdid mutation (0 available); any Smn1 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of 12 days

nervous system
N
• neuromuscular junctions are similar to controls in the intercostal and triangularis sterni muscles
• decrease in cardiac autonomic innervation
• in L3-L5 spinal cord sections but not in the cervical or thoracic regions

cardiovascular system
• end-stage mice display skipped or dropped beats
• at P9-P11
• at P9-P11

behavior/neurological
N
• ambulatory throughout life
• early in life
• outgrow this passive behavior after P6
• lateral instability of the hind limbs
• significantly improved righting response

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Werdnig-Hoffmann disease DOID:13137 OMIM:253300
J:183080


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory