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Phenotypes Associated with This Genotype
Genotype
MGI:5318530
Allelic
Composition		 Notch1tm2Rko/Notch1tm2Rko
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Notch1tm2Rko mutation (3 available); any Notch1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:181120 )
• mutant mice are not viable and die at birth

craniofacial
craniofacial phenotype ( J:181120 )
N
• normal palate formation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory