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Phenotypes Associated with This Genotype
Genotype
MGI:5317843
Allelic
Composition		 Ccr5tm1Kuz/Ccr5tm1Kuz
Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5tm1Kuz mutation (2 available); any Ccr5 mutation (29 available)
Cxcr4tm1Qma mutation (1 available); any Cxcr4 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:132342 )
• abrogated neurotoxicity to gp120 from a CCR5 preferring isolate of HIV
• abrogated neurotoxicity to gp120 from a CCR4 preferring isolate of HIV

immune system
decreased susceptibility to Retroviridae infection ( J:132342 )
• abrogated neurotoxicity to gp120 from a CCR5 preferring isolate of HIV
• abrogated neurotoxicity to gp120 from a CCR4 preferring isolate of HIV

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory