Phenotypes Associated with This Genotype

Genotype
MGI:5316396

• Allelic Composition: Fmr1^tm1Cgr/Y
• Genetic Background: B6.129P2-Fmr1^tm1Cgr/Nwu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:171069 )

♂N • Background Sensitivity: levels of spontaneous alternation and entries into maze arms are increased on the FVB background as compared to the C57BL/6 background, however, exploration does not differ between mutant and wild-type

♂N • Background Sensitivity: mice exhibit an increase in the number of vocalization and duration on FVB background as compared to the C57BL/6 background

increased aggression towards mice ( J:171069 )

♂ • Background Sensitivity: mice on the C57BL/6 background, but not the FVB background, exhibit an increased tendency to attack a juvenile stimulus mouse

abnormal response to novelty ( J:171069 )

♂ • mice do not preferentially explore the novelty stimulus mouse as compared to the familiar mouse in the social novelty preference test

increased grooming behavior ( J:171069 )

♂ • Background Sensitivity: mice spend more time self-grooming; the effect is more pronounced on the C57BL/6 background as compared to the FVB background

decreased startle reflex ( J:171069 )

♂ • startle response is less prominent with increased pulse intensity as compared to wild-type

♂ • Background Sensitivity: mice on the C57BL/6 background exhibit stronger responses to 100 dBa pulse and lower responses to the 120 dBa pulse as compared to FVB

abnormal locomotor activation ( J:171069 )

♂ • overall locomotor activity is increased as compared to wild-type

♂ • Background Sensitivity: mice on the FVB background are more active as compared to the C57BL/6 background

abnormal social investigation ( J:171069 )

♂ • mice do not preferentially explore the novelty stimulus mouse as compared to the familiar mouse in the social novelty preference test

♂ • Background Sensitivity: mice spend less time in non-social activities; the effect is more pronounced on the FVB background as compared to C57BL/6

♂ • Background Sensitivity: mice spend less time in affiliative behaviors; the effect is more pronounced on the C57BL/6 background as compared to FVB

nervous system

increased prepulse inhibition ( J:171069 )

♂ • Background Sensitivity: magnitude of prepulse inhibition is enhanced although the effect is more prominent on the C57BL/6 background as compared to the FVB background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:171069