Mouse Genome Informatics
ot
    Fmr1tm1Cgr/Y
B6.129P2-Fmr1tm1Cgr/Nwu
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• Background Sensitivity: levels of spontaneous alternation and entries into maze arms are increased on the FVB background as compared to the C57BL/6 background, however, exploration does not differ between mutant and wild-type
• Background Sensitivity: mice exhibit an increase in the number of vocalization and duration on FVB background as compared to the C57BL/6 background
• Background Sensitivity: mice on the C57BL/6 background, but not the FVB background, exhibit an increased tendency to attack a juvenile stimulus mouse
• mice do not preferentially explore the novelty stimulus mouse as compared to the familiar mouse in the social novelty preference test
• Background Sensitivity: mice spend more time self-grooming; the effect is more pronounced on the C57BL/6 background as compared to the FVB background
• startle response is less prominent with increased pulse intensity as compared to wild-type
• Background Sensitivity: mice on the C57BL/6 background exhibit stronger responses to 100 dBa pulse and lower responses to the 120 dBa pulse as compared to FVB
• overall locomotor activity is increased as compared to wild-type
• Background Sensitivity: mice on the FVB background are more active as compared to the C57BL/6 background
• mice do not preferentially explore the novelty stimulus mouse as compared to the familiar mouse in the social novelty preference test
• Background Sensitivity: mice spend less time in non-social activities; the effect is more pronounced on the FVB background as compared to C57BL/6
• Background Sensitivity: mice spend less time in affiliative behaviors; the effect is more pronounced on the C57BL/6 background as compared to FVB

nervous system
• Background Sensitivity: magnitude of prepulse inhibition is enhanced although the effect is more prominent on the C57BL/6 background as compared to the FVB background

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:171069