About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5315749
Allelic
Composition
Wdr19twto/Wdr19twto
Genetic
Background
involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr19twto mutation (0 available); any Wdr19 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cellular
• decrease in the percentage of cells with cilium in serum starved MEFs

muscle
• major disruption to the organization of the medial and lateral myotome
• major disruption to the organization of the medial and lateral dermomyotome

skeleton
• loss or truncation of several major bones of the skull
• appears to be absent
• intraparietal bones are severely hypoplastic
• appears to be absent
• mandible rests at a wider angle resulting in an open bite in embryos
• truncated
• misshapen and truncated
• misshapen and truncated
• truncated
• digit 1 is triphalangeal rather than biphalangeal
• tibial agenesis is consistently seen
• ossification centers are misaligned
• partially split
• marked branching
• marked
• marked
• lack of curvature
• disordered arrangements

vision/eye
• in most embryos

embryo
• fewer ciliated mesenchymal cells in the limbs at E10.5
• decrease is more marked on the mesenchyme than in the epithelium
• bifurcation and incomplete separation of adjacent somite segments at E10.5 and E11.5

limbs/digits/tail
• digit 1 is triphalangeal rather than biphalangeal
• an ectopic digit is often seen anterior to digit 1
• ectopic digit tips generated by branching at the joints are sometimes present
• fore and hindlimb polydactyly
• an ectopic digit is often seen anterior to digit 1
• ectopic digit tips generated by branching at the joints are sometimes present
• tibial agenesis is consistently seen
• fewer ciliated mesenchymal cells in the limbs at E10.5
• decrease is more marked on the mesenchyme than in the epithelium
• wider limb paddle at E10.5

nervous system
• almost completely penetrant at E17.5-E18.5

craniofacial
• loss or truncation of several major bones of the skull
• appears to be absent
• intraparietal bones are severely hypoplastic
• appears to be absent
• mandible rests at a wider angle resulting in an open bite in embryos
• truncated
• misshapen and truncated
• misshapen and truncated
• truncated
• failure in the medial and lateral nasal processes to meet and fuse with each other and with the maxilla at E11.5, E12.5, and E15.5
• overall truncation of the upper face
• severe bilateral cleft lip
• palatal shelves fail to extend vertically to the tongue at E13.5 but rather appear to crowd the oral cavity above the tongue
• in some cases the shelves meet but fail to fuse at E15.5

hearing/vestibular/ear

digestive/alimentary system
• palatal shelves fail to extend vertically to the tongue at E13.5 but rather appear to crowd the oral cavity above the tongue
• in some cases the shelves meet but fail to fuse at E15.5

growth/size/body
• overall truncation of the upper face
• severe bilateral cleft lip
• palatal shelves fail to extend vertically to the tongue at E13.5 but rather appear to crowd the oral cavity above the tongue
• in some cases the shelves meet but fail to fuse at E15.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ciliopathy DOID:0060340 J:181888


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/11/2019
MGI 6.14
The Jackson Laboratory