Phenotypes Associated with This Genotype

Genotype
MGI:5315472

• Allelic Composition: Spata22^repro42/Spata22^repro42
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

absent oocytes ( J:182054 )

♀

azoospermia ( J:182054 )

♂

decreased spermatid number ( J:182054 )

♂ • absent

abnormal spermatocyte morphology ( J:182054 )

♂ • mice lack some stages of spermatocytes

abnormal female meiosis ( J:182054 )

♀ • meiotic arrest with impaired synapsis and DNA repair

abnormal ovarian follicle morphology ( J:182054 )

♀ • degenerating

small ovary ( J:182054 )

♀

hemorrhagic ovary cyst ( J:182054 )

♀ • hemorrhagic cysts

decreased testis weight ( J:182054 )

♂

arrest of spermatogenesis ( J:182054 )

♂ • at stage IV

arrest of male meiosis ( J:182054 )

♂ • at prophase I with impaired synapsis and DNA repair

female infertility ( J:182054 )

♀

male infertility ( J:182054 )

♂

cellular

absent oocytes ( J:182054 )

♀

azoospermia ( J:182054 )

♂

decreased spermatid number ( J:182054 )

♂ • absent

abnormal spermatocyte morphology ( J:182054 )

♂ • mice lack some stages of spermatocytes

abnormal female meiosis ( J:182054 )

♀ • meiotic arrest with impaired synapsis and DNA repair

arrest of male meiosis ( J:182054 )

♂ • at prophase I with impaired synapsis and DNA repair

impaired double-strand DNA break repair ( J:182054 )

• impaired in oocytes and spermatocytes

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:182054 )

♀ • degenerating

small ovary ( J:182054 )

♀

hemorrhagic ovary cyst ( J:182054 )

♀ • hemorrhagic cysts

decreased testis weight ( J:182054 )

♂

homeostasis/metabolism

impaired double-strand DNA break repair ( J:182054 )

• impaired in oocytes and spermatocytes

growth/size/body

hemorrhagic ovary cyst ( J:182054 )

♀ • hemorrhagic cysts