Phenotypes Associated with This Genotype

Genotype
MGI:5315121

• Allelic Composition: Bcl2l11^tm1Ast/Bcl2l11^tm1Ast; Dicer1^tm1Bdh/Dicer1^tm1Bdh; Aicda^tm1(cre)Njen/Aicda⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:181782 )

• rescued germinal center B cells cannot effectively differentiate into antibody-secreting cells (AScs), and fail to differentiate into high affinity ASCs

decreased germinal center B cell number ( J:181782 )

• numbers are reduced in spleen relative to wild-type, but are dramatically increased on a Bcl2l11-deficient background compared to conditional knockouts with wild-type background

decreased plasma cell number ( J:181782 )

• NP-specific IgG1 antibody-secreting cells (ASCs) are present only at 20-25% of the numbers observed in wild-type spleens at day 12 after immunization

• high affinity ASCs are almost undetectable and bone marrow

hematopoietic system

abnormal B cell differentiation ( J:181782 )

• rescued germinal center B cells cannot effectively differentiate into antibody-secreting cells (AScs), and fail to differentiate into high affinity ASCs

decreased germinal center B cell number ( J:181782 )

• numbers are reduced in spleen relative to wild-type, but are dramatically increased on a Bcl2l11-deficient background compared to conditional knockouts with wild-type background

decreased plasma cell number ( J:181782 )

• NP-specific IgG1 antibody-secreting cells (ASCs) are present only at 20-25% of the numbers observed in wild-type spleens at day 12 after immunization

• high affinity ASCs are almost undetectable and bone marrow