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Phenotypes Associated with This Genotype
Genotype
MGI:5314906
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Huwe1tm1.1Mak mutation (1 available); any Huwe1 mutation (62 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:181705 )
N
• bone marrow B cell development and stimulated and unstimulated splenic B cell proliferation are restored compared to in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice
abnormal class switch recombination ( J:181705 )
• to a greater extent than in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice following stimulation of B cells with LPS or LPS plus IL4
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity

hematopoietic system
abnormal class switch recombination ( J:181705 )
• to a greater extent than in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice following stimulation of B cells with LPS or LPS plus IL4
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory