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Phenotypes Associated with This Genotype
Genotype
MGI:5314905
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Genetic
Background		 B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Huwe1tm1.1Mak mutation (1 available); any Huwe1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:181705 )
• in pre-B cells and mature B cells (1.5-fold)
decreased B cell proliferation ( J:181705 )
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4
abnormal B cell differentiation ( J:181705 )
• partially blocked at pre-B stage
abnormal class switch recombination ( J:181705 )
• following stimulation of B cells with LPS or LPS plus IL4
decreased mature B cell number ( J:181705 )
• 3-fold for recirculating mature B cells due to increased apoptosis
• of B220+IgM+ B cells in the spleen
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity
decreased pre-B cell number ( J:181705 )
• due to increased apoptosis
abnormal humoral immune response ( J:181705 )
• mice stimulated with a T-independent antigen, TNP-Ficoll, fail to mount a TNP-specific IgM or IgG3 unlike control mice
• mice stimulated with a T-dependent antigen, NP(15)CGG, produce less NP-specific IgG1 compared with control mice
decreased IgA level ( J:181705 )
• 4.5-fold in unstimulated mice
decreased IgG1 level ( J:181705 )
• 2-fold in unstimulated mice
• in mice stimulated with NP(15)CGG
decreased IgG2a level ( J:181705 )
• 32-fold in unstimulated mice
decreased IgG3 level ( J:181705 )
• 37-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
decreased IgM level ( J:181705 )
• 2.5-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
increased susceptibility to Riboviria infection ( J:181705 )
• mice infected with vesicular stomatitis virus (VSV) exhibit delayed anti-VSV antibody production and reduced anti-VSV IgG levels compared with control mice

cellular
increased B cell apoptosis ( J:181705 )
• in pre-B cells and mature B cells (1.5-fold)
decreased B cell proliferation ( J:181705 )
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4

hematopoietic system
increased B cell apoptosis ( J:181705 )
• in pre-B cells and mature B cells (1.5-fold)
decreased B cell proliferation ( J:181705 )
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4
abnormal B cell differentiation ( J:181705 )
• partially blocked at pre-B stage
abnormal class switch recombination ( J:181705 )
• following stimulation of B cells with LPS or LPS plus IL4
decreased mature B cell number ( J:181705 )
• 3-fold for recirculating mature B cells due to increased apoptosis
• of B220+IgM+ B cells in the spleen
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity
decreased pre-B cell number ( J:181705 )
• due to increased apoptosis
decreased IgA level ( J:181705 )
• 4.5-fold in unstimulated mice
decreased IgG1 level ( J:181705 )
• 2-fold in unstimulated mice
• in mice stimulated with NP(15)CGG
decreased IgG2a level ( J:181705 )
• 32-fold in unstimulated mice
decreased IgG3 level ( J:181705 )
• 37-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
decreased IgM level ( J:181705 )
• 2.5-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory