Phenotypes Associated with This Genotype

Genotype
MGI:5312683

• Allelic Composition: Ebi3^tm1Nkma/Ebi3^tm1Nkma; Fas^lpr/Fas^lpr
• Genetic Background: MRL.Cg-Ebi3^tm1Nkma Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:181669 )

• 90% survival at 20 weeks compared to 50% survival for MRL/lpr controls

renal/urinary system

abnormal glomerular capillary morphology ( J:181669 )

• generalized thickening of the capillary walls

• widespread discrete granular Ig deposition in the capillary walls, primarily IgG1 rather than IgG2a

increased urine protein level ( J:181669 )

• proteinuria increased relative to MRL/lpr controls

abnormal kidney physiology ( J:181669 )

abnormal renal protein reabsorption ( J:181669 )

• proteinuria increased relative to MRL/lpr controls

homeostasis/metabolism

decreased circulating creatine level ( J:181669 )

• suppressed relative to MRL/lpr controls

abnormal blood homeostasis ( J:181669 )

decreased circulating creatinine level ( J:181669 )

• serum creatinine is suppressed relative to MRL/lpr controls

decreased blood urea nitrogen level ( J:181669 )

• suppressed relative to MRL/lpr controls

abnormal cytokine level ( J:181669 )

decreased circulating interferon-gamma level ( J:181669 )

increased circulating interleukin-4 level ( J:181669 )

abnormal renal protein reabsorption ( J:181669 )

• proteinuria increased relative to MRL/lpr controls

increased urine protein level ( J:181669 )

• proteinuria increased relative to MRL/lpr controls

immune system

increased immunoglobulin level ( J:181669 )

increased IgE level ( J:181669 )

increased IgG level ( J:181669 )

increased IgG1 level ( J:181669 )

abnormal cytokine level ( J:181669 )

decreased circulating interferon-gamma level ( J:181669 )

increased circulating interleukin-4 level ( J:181669 )

cardiovascular system

abnormal glomerular capillary morphology ( J:181669 )

• generalized thickening of the capillary walls

• widespread discrete granular Ig deposition in the capillary walls, primarily IgG1 rather than IgG2a

hematopoietic system

increased immunoglobulin level ( J:181669 )

increased IgE level ( J:181669 )

increased IgG level ( J:181669 )

increased IgG1 level ( J:181669 )