Phenotypes Associated with This Genotype

Genotype
MGI:5312326

• Allelic Composition: Apc^tm1Rak/Apc⁺; Dcc^tm1.1Mehl/Dcc^tm1.1Mehl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased gastrointestinal tumor incidence ( J:181517 )

• all mice have tumors whereas 21.4% of heterozygous Apc^tm1Rak controls are tumor free

• tumor apoptosis rate in adenomas is reduced

increased intestinal adenocarcinoma incidence ( J:181517 )

• 100% have adenocarcenomas

increased metastatic potential ( J:181517 )

• 45.5% of tumors involve serosal invasion compared to 8% in controls

• micrometastatic lesions are found in the liver when serosal invasion occurs

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:181517 )

• all mice have tumors whereas 21.4% of heterozygous Apc^tm1Rak controls are tumor free

• tumor apoptosis rate in adenomas is reduced

increased intestinal adenocarcinoma incidence ( J:181517 )

• 100% have adenocarcenomas