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Phenotypes Associated with This Genotype
Genotype
MGI:5312301
Allelic
Composition		 \Ercc6tm1Gvh/\Ercc6tm1Gvh
\Xpatm1Gvh/\Xpatm1Hvs
\Tg(Pcp2-cre)2Mpin/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6tm1Gvh mutation (1 available); any Ercc6 mutation (78 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
Xpatm1Gvh mutation (0 available); any Xpa mutation (21 available)
Xpatm1Hvs mutation (3 available); any Xpa mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Neurodegenerative changes in Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(Pcp2-cre)2Mpin/0 mice

nervous system
axon degeneration ( J:179808 )
• argyrophilic axonal degeneration in the cerebellar white matter and cerebellar nuclei

immune system

hematopoietic system

cellular

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory