Phenotypes Associated with This Genotype

Genotype
MGI:5312061

• Allelic Composition: Gsdma3^Ae/Gsdma3⁺
• Genetic Background: involves: C57BL/6J * CAST/Ei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal skin adnexa morphology ( J:180149 )

abnormal coat appearance ( J:180149 )

• rough hair coat at 16 days

progressive hair loss ( J:180149 )

• hair loss beginning around eye lids at 22 days of age

• nearly complete hair loss in both sexes at 6 months of age

• hair loss on tail as well

• vibrissae are normal

abnormal hair cuticle ( J:166522 )

• cuticle cells on hair shaft lack the overlapping pattern of controls

• cuticle cells flattened rather than scale-like

thin hair shaft ( J:166522 )

abnormal hair follicle bulge morphology ( J:180149 )

• stem cell numbers are significantly reduced

abnormal hair cycle ( J:180149 )

• hair plucking has a reduced ability to induce new hair cycles

abnormal hair cycle catagen phase ( J:180149 )

• delayed at 16 days

delayed hair regrowth ( J:180149 )

• delay of later hair cycles starting with the second

abnormal skin morphology ( J:180149 )

epidermal hyperplasia ( J:180149 )

• hyperplastic zone extends from thd boundry of the dermis and subcutis at 16 days of age

wrinkled skin ( J:180149 )

• thickened and wrinkled skin starting around 7 days of age

abnormal skin physiology ( J:180149 )

• moderate to severe excoriation and erosion of dermis in some mice at 6 months of age

skin inflammation ( J:180149 )

• severe

• inflammatory cells in dermis at 7 days, more extensive at 13 days

• increased expression of markers for macrophage on the border between the dermis and subcutis at 13 days of age

immune system

enlarged thymus ( J:180149 )

• slightly enlarged

enlarged spleen ( J:180149 )

• slightly enlarged

enlarged lymph nodes ( J:180149 )

• inguinal lymph nodes

• shoulder anterior lymph nodes

• axial lymph nodes

skin inflammation ( J:180149 )

• severe

• inflammatory cells in dermis at 7 days, more extensive at 13 days

• increased expression of markers for macrophage on the border between the dermis and subcutis at 13 days of age

vision/eye

cornea opacity ( J:180149 )

• in older mice

hematopoietic system

enlarged thymus ( J:180149 )

• slightly enlarged

enlarged spleen ( J:180149 )

• slightly enlarged

endocrine/exocrine glands

enlarged thymus ( J:180149 )

• slightly enlarged

growth/size/body

enlarged spleen ( J:180149 )

• slightly enlarged