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Phenotypes Associated with This Genotype
Genotype
MGI:5312061
Allelic
Composition
Gsdma3Ae/Gsdma3+
Genetic
Background
involves: C57BL/6J * CAST/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdma3Ae mutation (0 available); any Gsdma3 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• rough hair coat at 16 days
• hair loss beginning around eye lids at 22 days of age
• nearly complete hair loss in both sexes at 6 months of age
• hair loss on tail as well
• vibrissae are normal
• cuticle cells on hair shaft lack the overlapping pattern of controls
• cuticle cells flattened rather than scale-like
• stem cell numbers are significantly reduced
• hair plucking has a reduced ability to induce new hair cycles
• delayed at 16 days
• delay of later hair cycles starting with the second
• hyperplastic zone extends from thd boundry of the dermis and subcutis at 16 days of age
• thickened and wrinkled skin starting around 7 days of age
• moderate to severe excoriation and erosion of dermis in some mice at 6 months of age
• severe
• inflammatory cells in dermis at 7 days, more extensive at 13 days
• increased expression of markers for macrophage on the border between the dermis and subcutis at 13 days of age

immune system
• slightly enlarged
• slightly enlarged
• inguinal lymph nodes
• shoulder anterior lymph nodes
• axial lymph nodes
• severe
• inflammatory cells in dermis at 7 days, more extensive at 13 days
• increased expression of markers for macrophage on the border between the dermis and subcutis at 13 days of age

vision/eye
• in older mice

hematopoietic system
• slightly enlarged
• slightly enlarged

endocrine/exocrine glands
• slightly enlarged

growth/size/body
• slightly enlarged


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory