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Phenotypes Associated with This Genotype
Genotype
MGI:5311113
Allelic
Composition		 Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)3Amc/0
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Runx2tm1Mjo mutation (0 available); any Runx2 mutation (44 available)
Tg(Col2a1-cre)3Amc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:180304 )
N
• unlike Runx2tm1Mjo homozygotes, mice exhibit normal bone collar
abnormal bone marrow cavity morphology ( J:180304 )
• like Runx2tm1Mjo homozygotes, mice lack a marrow cavity
abnormal bone ossification ( J:180304 )
• at E18.5, bone formation defects observed in Runx2tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory