Phenotypes for Gt(ROSA)26Sor Runx2 Tg(Col2a1-cre)3Amc MGI:5311112 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm3(Runx2)Flng}/Gt(ROSA)26Sor^{tm3(Runx2)Flng} Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Col2a1-cre)3Amc/0
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(Runx2)Flng} mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Runx2^tm1Mjo mutation (0 available); any Runx2 mutation (44 available)
Tg(Col2a1-cre)3Amc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:180304 )

N	• unlike Runx2^tm1Mjo homozygotes, mice exhibit normal cartilage, bone collar, and marrow and restored osteoblast differentiation and cartilage hypertrophy

abnormal bone ossification ( J:180304 )

• at E18.5, bone formation defects observed in Runx2^tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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