Phenotypes Associated with This Genotype

Genotype
MGI:5308805

• Allelic Composition: Dcc^tm1Nki/Dcc^tm1Nki; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)8Brn/?
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:181090 )

• metastasis is much more frequent (6 out of 14 cases) than when Dcc is un-mutated or mutation is heterozygous

• metastases are found in draining lymph nodes and/or lungs

increased tumor incidence ( J:181090 )

• high tumor incidence (80%) of mammary tumors regardless of presence or zygosity of Dcc mutation

• single or multiple independent tumors

increased classified tumor incidence ( J:181090 )

• solid tumors with clear demarcations

increased mammary adenocarcinoma incidence ( J:181090 )

increased spindle cell carcinoma incidence ( J:181090 )

• in mammary glands

abnormal tumor latency ( J:181090 )

• tumor latency of mammary tumors is not modified by the presence or zygosity of Dcc mutation

cellular

decreased apoptosis ( J:181090 )

• tumor cells in culture cannot be induced to apoptosis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:181090 )

integument

increased mammary adenocarcinoma incidence ( J:181090 )