Phenotypes Associated with This Genotype

Genotype
MGI:5308222

• Allelic Composition: Gars1^C201R/Gars1^C201R; Tg(CAG-GARS)DRwb/0
• Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:179811 )

N • mutants are born at the expected Mendelian ratios, indicating rescue of the prenatal lethality seen in homozygotes

postnatal lethality, complete penetrance ( J:179811 )

• mutants live to a maximum of P20

growth/size/body

decreased body weight ( J:179811 )

nervous system

abnormal axon morphology ( J:179811 )

• mutants exhibit a 50% reduction in axon numbers in the motor branch of the femoral nerve

abnormal neuromuscular synapse morphology ( J:179811 )

• mutants exhibit neuromuscular junction defects, with frank denervation at almost half of the postsynaptic sites

decreased nerve conduction velocity ( J:179811 )

• impaired nerve conduction velocities