Phenotypes Associated with This Genotype

Genotype
MGI:5308215

• Allelic Composition: Afdn^tm1.1Lfr/Afdn^tm1.1Lfr; Neurod6^tm1(cre)Kan/Neurod6⁺
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:179366 )

• decrease in the densities of alpha-catenin, beta-N-catenin and EphB receptor puncta

• lower density of excitatory synapses in the CA1- stratum radiatum

• increase in average presynaptic terminal area in the CA1- stratum radiatum

abnormal hippocampus pyramidal cell morphology ( J:179366 )

• display a 43% decrease in spine density

ectopic hippocampus pyramidal cells ( J:179366 )

• a small number of CA1 pyramidal cell bodies are mislocalized to the stratum oriens (10%) or stratum radiatum (5%)

abnormal synapse morphology ( J:179366 )

• lower density of excitatory synapses in the CA1- stratum radiatum

• increase in average presynaptic terminal area in the CA1- stratum radiatum

abnormal excitatory postsynaptic potential ( J:179366 )

• lower field EPSPs in the CA1 region of the hippocampus

• however, the evoked fiber volley amplitude as a function of stimulus intensity is similar to controls indicating mutants have normal numbers of Schaffer collateral axons innervating CA1