Phenotypes Associated with This Genotype

Genotype
MGI:5308213

• Allelic Composition: Gars1^Nmf249/Gars1⁺; Tg(CAG-GARS)DRwb/0
• Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:179811 )

• mutants exhibit a similar decrease in body weight as single Gars^Nmf249 heterozygotes

nervous system

abnormal axon morphology ( J:179811 )

• mutants exhibit a similar reduction in axon numbers in motor and sensory nerves as single Gars^Nmf249 heterozygotes

abnormal neuromuscular synapse morphology ( J:179811 )

• neuromuscular junctions are disrupted to a similar extent as in Gars^Nmf249 heterozygotes

decreased nerve conduction velocity ( J:179811 )

• nerve conduction velocities are similar to single Gars^Nmf249 heterozygotes