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Phenotypes Associated with This Genotype
Genotype
MGI:5308087
Allelic
Composition		 Cd207tm2.1(cre)Bjec/Cd207+
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd207tm2.1(cre)Bjec mutation (0 available); any Cd207 mutation (24 available)
Tgfbr1tm1.1Karl mutation (1 available); any Tgfbr1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased dendritic cell number ( J:179630 )
• mice lack almost all CD207-positive dendritic cells (DCs) in the epidermis
abnormal type IV hypersensitivity reaction ( J:179630 )
• contact hypersensitivity assessed by ear swelling is attenuated at 24 hours after hapten challenge relative to wild-type controls

hematopoietic system
decreased dendritic cell number ( J:179630 )
• mice lack almost all CD207-positive dendritic cells (DCs) in the epidermis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory