Phenotypes Associated with This Genotype

Genotype
MGI:5307250

• Allelic Composition: Kit^W/Kit^W-v
• Genetic Background: (WB Kit^W x B6.Cg-Kit^W-v)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:197334 )

• following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit increased plasma histamine levels or temporary decrease in rectal temperature unlike wild-type mice

decreased susceptibility to induced arthritis ( J:178942 )

• after receiving i.p. injections of K/BxN mouse serum in an antibody-induced (autoimmune) arthritis model, mice are protected from arthritis, except for mild and transient symptoms

skeleton

decreased susceptibility to induced arthritis ( J:178942 )

• after receiving i.p. injections of K/BxN mouse serum in an antibody-induced (autoimmune) arthritis model, mice are protected from arthritis, except for mild and transient symptoms

homeostasis/metabolism

abnormal circulating histamine level ( J:197334 )

• following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit increased plasma histamine levels unlike wild-type mice

abnormal body temperature ( J:197334 )

• following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit temporary decrease in rectal temperature unlike wild-type mice