Phenotypes for Kit MGI:5307249 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	involves: C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (6 available); any Kit mutation (175 available)
Kit^W-v mutation (9 available); any Kit mutation (175 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:178942 )

N	• after 6 weeks of exposure to phorbol myristate acetate (PMA), a 10 to 100 fold increase in mast cells in the normally deficient skin is observed; wild-type mice exhibit a 3-4-fold increase following chronic inflammation

decreased basophil cell number ( J:178942 )

• mice show reduced numbers of splenic basophils

decreased mast cell number ( J:178942 )

• mice have no peritoneal or connective tissue mast cells

hematopoietic system

decreased basophil cell number ( J:178942 )

• mice show reduced numbers of splenic basophils

decreased mast cell number ( J:178942 )

• mice have no peritoneal or connective tissue mast cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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