Phenotypes Associated with This Genotype

Genotype
MGI:5306890

• Allelic Composition: Casr^tm1Wch/Casr⁺; Tg(PTH-cre)4167Slib/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:180651 )

N • mice exhibit normal trabecular bone connectivity density and trabeculae spacing

decreased bone mineral density ( J:180651 )

• mild by 6 months of age

decreased compact bone volume ( J:180651 )

decreased compact bone thickness ( J:180651 )

decreased bone trabecula number ( J:180651 )

decreased trabecular bone thickness ( J:180651 )

homeostasis/metabolism

increased circulating parathyroid hormone level ( J:180651 )

increased circulating calcium level ( J:180651 )

increased urine calcium level ( J:180651 )

renal/urinary system

increased urine calcium level ( J:180651 )