Phenotypes Associated with This Genotype

Genotype
MGI:5306889

• Allelic Composition: Casr^tm1Wch/Casr^tm1Wch; Tg(PTH-cre)4167Slib/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:180651 )

• mice die within 2 weeks of birth

skeleton

abnormal skeleton morphology ( J:180651 )

• small, fragile, and undermineralized skeleton

decreased bone mineral content ( J:180651 )

• in trabecular and cortical bones

decreased bone mineral density ( J:180651 )

abnormal skeleton development ( J:180651 )

• retarded

decreased bone mineralization ( J:180651 )

• undermineralized skeleton

fragile skeleton ( J:180651 )

homeostasis/metabolism

increased circulating parathyroid hormone level ( J:180651 )

increased circulating calcium level ( J:180651 )

increased urine calcium level ( J:180651 )

renal/urinary system

increased urine calcium level ( J:180651 )

growth/size/body

decreased body weight ( J:180651 )

postnatal growth retardation ( J:180651 )

• growth is severely blunted