Phenotypes Associated with This Genotype

Genotype
MGI:5306777

• Allelic Composition: Vps35^{Gt(RRK261)Byg}/Vps35⁺; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35^{Gt(RRK261)Byg}/Vps35⁺ Tg(APPSWE)2576Kha/0 mice

nervous system

nervous system phenotype ( J:178937 )

N • mice exhibit normal paired-pulse facilitation and inhibitory synaptic transmission

amyloid beta deposits ( J:178937 )

• in the hippocampus and cerebral cortex

• greater accumulation than in Tg(APPSWE)2576Kha mice

impaired synaptic plasticity ( J:178937 )

• accelerated compared to in Tg(APPSWE)2576Kha mice

abnormal excitatory postsynaptic potential ( J:178937 )

• field excitatory postsynaptic potential slopes in the CA1 and dentate gyrus are reduced compared to in either single heterozygotes

reduced AMPA-mediated synaptic currents ( J:178937 )

• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice

reduced NMDA-mediated synaptic currents ( J:178937 )

• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice

reduced long-term potentiation ( J:178937 )

• in the CA1 at 2 months

• worsened at 4 months in the CA1

• however, long term potentiation in the dentate gyrus is normal

abnormal miniature excitatory postsynaptic currents ( J:178937 )

• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice

decreased post-tetanic potentiation ( J:178937 )

• at 4 months in the CA1

behavior/neurological

abnormal spatial learning ( J:178937 )

• in a Morris water maze, mice exhibit increased latencies to finding the hidden platform and in pathway length compared with either single heterozygote

• deficits increase with age

homeostasis/metabolism

amyloid beta deposits ( J:178937 )

• in the hippocampus and cerebral cortex

• greater accumulation than in Tg(APPSWE)2576Kha mice