Phenotypes Associated with This Genotype

Genotype
MGI:5305973

• Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak; Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst}
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:180054 )

• mice die within 6 months of birth

prenatal lethality, incomplete penetrance ( J:180054 )

• slightly fewer than expected mice are born alive

immune system

spleen hyperplasia ( J:180054 )

increased neutrophil cell number ( J:180054 )

increased susceptibility to systemic lupus erythematosus ( J:180054 )

• mice develop similar inflammatory disease (body weight loss, anemia, neutrophilia, leukocyte organ infiltrations, and glomerulonephritis) as observed in Tnip1^{Gt(E059E05)Wrst} homozygotes

glomerulonephritis ( J:180054 )

hematopoietic system

spleen hyperplasia ( J:180054 )

anemia ( J:180054 )

decreased hemoglobin content ( J:180054 )

increased neutrophil cell number ( J:180054 )

growth/size/body

decreased body weight ( J:180054 )

spleen hyperplasia ( J:180054 )

renal/urinary system

glomerulonephritis ( J:180054 )