Phenotypes Associated with This Genotype

Genotype
MGI:5305585

• Allelic Composition: Foxo1^tm2.1Dac/Foxo1^tm2.1Dac
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased energy expenditure ( J:179687 )

• in resting mice

decreased carbon dioxide production ( J:179687 )

decreased respiratory quotient ( J:179687 )

abnormal glucose homeostasis ( J:179687 )

• mice exhibit decreased glucose infusion rates compared with wild-type mice

• however, mice exhibit normal whole body glucose uptake and glycolysis

increased circulating glucose level ( J:179687 )

• in fasting and re-fed mice

increased circulating insulin level ( J:179687 )

• in fasting, but not re-fed, mice

abnormal gluconeogenesis ( J:179687 )

• under maximal insulin concentrations, hepatic glucose production is 2.5-fold compared to in wild-type mice

insulin resistance ( J:179687 )

abnormal lipid homeostasis ( J:179687 )

• de novo lipogenesis is decreased compared to in wild-type mice

decreased circulating cholesterol level ( J:179687 )

• in fasting mice

decreased circulating free fatty acids level ( J:179687 )

• in fasting and re-fed mice

decreased circulating triglyceride level ( J:179687 )

• in re-fed, but not fasting, mice

decreased circulating VLDL triglyceride level ( J:179687 )

decreased liver triglyceride level ( J:179687 )

• in re-fed mice

adipose tissue

abnormal adipose tissue physiology ( J:179687 )

• isoproterenol-stimulated glycerol release from cultured epididymal fat pads is increased compared to in wild-type cells

• however, basal levels are normal

liver/biliary system

decreased liver triglyceride level ( J:179687 )

• in re-fed mice