Phenotypes Associated with This Genotype

Genotype
MGI:5304839

• Allelic Composition: Ptpn1^tm2Bbk/Ptpn1^tm2Bbk; Ptpn2^tm1.1Ttig/Ptpn2^tm1.1Ttig; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:179621 )

• whether fed standard chow or a high-fat diet, leptin-treated mice exhibit enhanced leptin sensitivity compared with wild-type mice

decreased circulating leptin level ( J:179621 )

• when fed standard chow

increased energy expenditure ( J:179621 )

• when fed standard chow

decreased susceptibility to diet-induced obesity ( J:179621 )

• when fed a high-fat diet

increased oxygen consumption ( J:179621 )

• when fed standard chow

abnormal respiratory quotient ( J:179621 )

• when fed standard chow, respiratory exchange ratio is decreased in the light cycle and increased in the dark cycle compared with wild-type mice

abnormal glucose homeostasis ( J:179621 )

• glucose homeostasis is improved in mice fed a high-fat diet compared to in wild-type mice

decreased circulating glucose level ( J:179621 )

• in fasted mice fed standard chow

increased insulin sensitivity ( J:179621 )

• when fed standard chow

growth/size/body

decreased body weight ( J:179621 )

• when fed standard chow

decreased body length ( J:179621 )

• when fed standard chow

decreased susceptibility to diet-induced obesity ( J:179621 )

• when fed a high-fat diet

behavior/neurological

abnormal eating behavior ( J:179621 )

• when fed standard chow