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Phenotypes Associated with This Genotype
Genotype
MGI:5304713
Allelic
Composition
Egln1tm1Kael/Egln1tm1Kael
Egln3tm1Vlcg/Egln3tm1Vlcg
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1Kael mutation (1 available); any Egln1 mutation (12 available)
Egln3tm1Vlcg mutation (0 available); any Egln3 mutation (16 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 5 weeks and severe at 8 weeks

mortality/aging
• mean survival is 29 weeks

cardiovascular system
• at 5 weeks and severe at 8 weeks
• at 8 weeks, mice exhibit reduced left ventricular wall thickness and increased left ventricular end-diastolic dimension compared with control mice
• at 5 weeks and severe at 8 weeks
• severe at 8 weeks of age

muscle
• at 5 weeks and severe at 8 weeks
• severe at 8 weeks of age

cellular
• myocytes exhibit mitochondrial loss

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiomyopathy DOID:0050700 J:179490


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory