Phenotypes Associated with This Genotype

Genotype
MGI:5304570

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Pdss2^tm1.1Jdhu/Pdss2^tm1.2Jdhu; Tg(Pcp2-cre)3555Jdhu/0
• Genetic Background: involves: 129 * C3H/HeNCr MMTV^- * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:179845 )

• at 9.5 months, mice exhibit failure in motor coordination during walking and incapability to maintain balance on a rod

ataxia ( J:179845 )

• gradual

impaired balance ( J:179845 )

abnormal gait ( J:179845 )

• mice exhibit shorter and more variable strides with more frequent additional steps made by both forepaw and hindpaw compared with wild-type mice

short stride length ( J:179845 )

• and more variable

nervous system

increased neuron apoptosis ( J:179845 )

• at 6 months in the cerebellum

Purkinje cell degeneration ( J:179845 )

• in the cerebellum of aged mice

decreased Purkinje cell number ( J:179845 )

• at 6 months in the cerebellum

cellular

increased neuron apoptosis ( J:179845 )

• at 6 months in the cerebellum