Phenotypes Associated with This Genotype

Genotype
MGI:5302396

• Allelic Composition: Mc3r^tm1Butl/Mc3r^tm1Butl; Tg(Nr5a1-cre)2Lowl/0
• Genetic Background: involves: C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased lean body mass ( J:178147 )

• on a standard chow diet

adipose tissue

abnormal adipose tissue amount ( J:178147 )

• increase in fat mass in mice on a standard diet is attenuated compared to homozygous mice not expressing the cre transgene

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:178147 )

N • unlike in homozygous mice not expressing the cre transgene, hyperinsulinemia, reduced energy expenditure per kg of body weight and reduced respiratory exchange ratio are not seen

abnormal circulating leptin level ( J:178147 )

• hyperleptinemia is partially attenuated compared to homozygous mice not expressing the cre transgene

decreased circulating triglyceride level ( J:178147 )

• lower levels of total triglycerides

abnormal energy homeostasis ( J:178147 )

• under a restricted feeding protocol more food is required to protect mice from weight loss exceeding 15% of initial body weight

behavior/neurological

abnormal locomotor activation ( J:178147 )

• partial rescue of reduced activity compared to homozygous mice not expressing the cre transgene

• food anticipatory activity is attenuated